On 15 September 2022, Science published the Research Article “Structural basis for strychnine activation of human bitter taste receptor TAS2R46” by W. Xu et al. (1). On 22 November 2022, an Editorial Expression of Concern alerted readers to concerns regarding fig. S10D (1). The authors have now corrected the paper, and the Editorial Expression of Concern has been replaced by an Erratum (3). As described in the Erratum, the authors repeated bioluminescence energy transfer experiments that were the basis for figs. S9, C to F, and S10D. The new data did not provide strong functional support for the structure-based suggestion of precoupling between TAS2R46 and the G protein gustducin. In the corrected version of the Research Article, Xiaoling Cao is no longer an author; figs. S9, C to F, and S10D have been removed; and the conclusions on precoupling are weaker than in the original version. The editors remain confident in the key findings of the paper: the cryo–electron microscopy structures of human TAS2R46 complexed with chimeric mini–G protein gustducin, in both strychnine-bound and apo forms.
Article source: https://www.science.org/doi/10.1126/science.adx7164